Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease

LRRK2 mutations are recognized as the most frequent genetic cause of both familial and sporadic parkinsonism identified to date. A remarkable feature of this form of parkinsonism is the variable penetrance of symptom manifestation resulting in a wide range of age-at-onset in patients. Herein we use...

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Detalhes bibliográficos
Main Authors: Dachsel, Justus C., Nishioka, Kenya, Vilariño-Güell, Carles, Lincoln, Sarah J., Soto-Ortolaza, Alexandra I., Kachergus, Jennifer, Hinkle, Kelly M., Heckman, Michael G., Jasinska-Myga, Barbara, Taylor, Julie P., Dickson, Dennis W., Gibson, Rachel A., Hentati, Faycal, Ross, Owen A., Farrer, Matthew J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847049/
https://ncbi.nlm.nih.gov/pubmed/20144646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2010.01.009
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