Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

The hypoxia-inducible factors (HIFs; isoforms HIF-1α, HIF-2α, HIF-3α) mediate many responses to hypoxia. Their regulation is principally by oxygen-dependent degradation, which is initiated by hydroxylation of specific proline residues followed by binding of von Hippel-Lindau (VHL) protein. Chuvash p...

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Main Authors: Formenti, Federico, Beer, Philip A., Croft, Quentin P. P., Dorrington, Keith L., Gale, Daniel P., Lappin, Terence R. J., Lucas, Guy S., Maher, Eamonn R., Maxwell, Patrick H., McMullin, Mary F., O'Connor, David F., Percy, Melanie J., Pugh, Christopher W., Ratcliffe, Peter J., Smith, Thomas G., Talbot, Nick P., Robbins, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2011
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159892/
https://ncbi.nlm.nih.gov/pubmed/21389259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-177378
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