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Inhibition of SOCS1(−/−) Lethal Auto-Inflammatory Disease Correlated to Enhanced Peripheral Foxp3(+) Regulatory T cell Homeostasis
SOCS1(−/−) mice, which are lymphopenic, die less than 3 weeks after birth of a T cell mediated autoimmune inflammatory disease characterized by leukocyte infiltration and destruction of vital organs. Notably, Foxp3(+) regulatory T cells (Tregs) have been shown to be particularly potent in inhibiting...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3159835/ https://ncbi.nlm.nih.gov/pubmed/21788442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003819 |
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