Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1

The ETS (E26) protein Elk-1 serves as a paradigm for mitogen-responsive transcription factors. It is multiply phosphorylated by mitogen-activated protein kinases (MAPKs), which it recruits into pre-initiation complexes on target gene promoters. However, events preparatory to Elk-1 phosphorylation ar...

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Bibliographische Detailangaben
Hauptverfasser: Evans, Emma L., Saxton, Janice, Shelton, Samuel J., Begitt, Andreas, Holliday, Nicholas D., Hipskind, Robert A., Shaw, Peter E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
Schlagworte:
Gene Regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159454/
https://ncbi.nlm.nih.gov/pubmed/21543455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr266
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