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De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation
ELK-1 is a transcription factor involved in ERK-induced cellular proliferation. Here, we show that its transcriptional activity is modulated by ubiquitination at lysine 35 (K35). The level of ubiquitinated ELK-1 rises in mitogen-deprived cells and falls upon mitogen stimulation or oncogene expressio...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6511843/ https://ncbi.nlm.nih.gov/pubmed/30854565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz166 |
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