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An RNA aptamer perturbs heat shock transcription factor activity in Drosophila melanogaster

Heat shock transcription factor (HSF1) is a conserved master regulator that orchestrates the protection of normal cells from stress. However, HSF1 also protects abnormal cells and is required for carcinogenesis. Here, we generate an highly specific RNA aptamer (iaRNA(HSF1)) that binds Drosophila HSF...

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Autors principals: Salamanca, H. Hans, Fuda, Nicholas, Shi, Hua, Lis, John T.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159435/
https://ncbi.nlm.nih.gov/pubmed/21576228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr206
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