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Inhibiting Heat Shock Factor 1 in Human Cancer Cells with a Potent RNA Aptamer
Heat shock factor 1 (HSF1) is a master regulator that coordinates chaperone protein expression to enhance cellular survival in the face of heat stress. In cancer cells, HSF1 drives a transcriptional program distinct from heat shock to promote metastasis and cell survival. Its strong association with...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4011729/ https://ncbi.nlm.nih.gov/pubmed/24800749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096330 |
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