HIV Type 1 Env Precursor Cleavage State Affects Recognition by Both Neutralizing and Nonneutralizing gp41 Antibodies

HIV-1 is relatively resistant to antibody-mediated neutralization; however, rare antibodies to the exterior envelope glycoprotein, gp120, and the transmembrane glycoprotein, gp41, can neutralize a broad array of isolates. Two antibodies, 2F5 and 4E10, are directed against the gp41 membrane proximal...

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Hlavní autoři: Chakrabarti, Bimal K., Pancera, Marie, Phogat, Sanjay, O'Dell, Sijy, McKee, Krisha, Guenaga, Javier, Robinson, James, Mascola, John, Wyatt, Richard T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2011
Témata:
Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159124/
https://ncbi.nlm.nih.gov/pubmed/21158699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2010.0281
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