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CODA-RET reveals functional selectivity as a result of GPCR heteromerization
Here we present a novel method that combines protein complementation with resonance energy transfer to study conformational changes in response to activation of a defined G protein-coupled receptor heteromer, and we apply the approach to the putative dopamine D1-D2 receptor heteromer. Remarkably, th...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158273/ https://ncbi.nlm.nih.gov/pubmed/21785426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.623 |
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