Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase

HsPKS1 from Huperzia serrata is a type III polyketide synthase (PKS) with remarkable substrate tolerance and catalytic potential. Here we present the synthesis of unnatural unique polyketide–alkaloid hybrid molecules by exploiting the enzyme reaction using precursor-directed and structure-based appr...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Morita, Hiroyuki, Yamashita, Makoto, Shi, She-Po, Wakimoto, Toshiyuki, Kondo, Shin, Kato, Ryohei, Sugio, Shigetoshi, Kohno, Toshiyuki, Abe, Ikuro
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158201/
https://ncbi.nlm.nih.gov/pubmed/21825160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107782108
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi