Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase

HsPKS1 from Huperzia serrata is a type III polyketide synthase (PKS) with remarkable substrate tolerance and catalytic potential. Here we present the synthesis of unnatural unique polyketide–alkaloid hybrid molecules by exploiting the enzyme reaction using precursor-directed and structure-based appr...

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Autors principals: Morita, Hiroyuki, Yamashita, Makoto, Shi, She-Po, Wakimoto, Toshiyuki, Kondo, Shin, Kato, Ryohei, Sugio, Shigetoshi, Kohno, Toshiyuki, Abe, Ikuro
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158201/
https://ncbi.nlm.nih.gov/pubmed/21825160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107782108
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