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Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase
HsPKS1 from Huperzia serrata is a type III polyketide synthase (PKS) with remarkable substrate tolerance and catalytic potential. Here we present the synthesis of unnatural unique polyketide–alkaloid hybrid molecules by exploiting the enzyme reaction using precursor-directed and structure-based appr...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158201/ https://ncbi.nlm.nih.gov/pubmed/21825160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107782108 |
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