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Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors)

P2X receptors are trimeric cation channels with widespread roles in health and disease. The recent crystal structure of a P2X4 receptor provides a 3D view of their topology and architecture. A key unresolved issue is how ions gain access to the pore, because the structure reveals two different pathw...

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Detalhes bibliográficos
Main Authors: Samways, Damien S. K., Khakh, Baljit S., Dutertre, Sébastien, Egan, Terrance M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158179/
https://ncbi.nlm.nih.gov/pubmed/21808018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017550108
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