Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer

In the majority of cases, advanced prostate cancer responds initially to androgen deprivation therapy by depletion of gonadal testosterone. The response is usually transient, and metastatic tumors almost invariably eventually progress as castration-resistant prostate cancer (CRPC). The development o...

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Bibliographic Details
Main Authors: Chang, Kai-Hsiung, Li, Rui, Papari-Zareei, Mahboubeh, Watumull, Lori, Zhao, Yan Daniel, Auchus, Richard J., Sharifi, Nima
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158152/
https://ncbi.nlm.nih.gov/pubmed/21795608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107898108
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