Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer

In the majority of cases, advanced prostate cancer responds initially to androgen deprivation therapy by depletion of gonadal testosterone. The response is usually transient, and metastatic tumors almost invariably eventually progress as castration-resistant prostate cancer (CRPC). The development o...

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Detalles Bibliográficos
Main Authors: Chang, Kai-Hsiung, Li, Rui, Papari-Zareei, Mahboubeh, Watumull, Lori, Zhao, Yan Daniel, Auchus, Richard J., Sharifi, Nima
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158152/
https://ncbi.nlm.nih.gov/pubmed/21795608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107898108
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