Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer

In the majority of cases, advanced prostate cancer responds initially to androgen deprivation therapy by depletion of gonadal testosterone. The response is usually transient, and metastatic tumors almost invariably eventually progress as castration-resistant prostate cancer (CRPC). The development o...

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Detalles Bibliográficos
Autores principales: Chang, Kai-Hsiung, Li, Rui, Papari-Zareei, Mahboubeh, Watumull, Lori, Zhao, Yan Daniel, Auchus, Richard J., Sharifi, Nima
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158152/
https://ncbi.nlm.nih.gov/pubmed/21795608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107898108
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