The sphingosine 1-phosphate receptor S1P2 maintains germinal center B cell homeostasis and promotes niche confinement

Sphingosine-1-phosphate receptor-2 (S1P2)-deficient mice develop diffuse large B cell lymphoma. However, the role of S1P2 in normal germinal center (GC) physiology is unknown. Here we show that S1P2-deficient GC B cells outgrow their wild-type counterparts in chronically-established GCs. We find tha...

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Detalhes bibliográficos
Main Authors: Green, Jesse A., Suzuki, Kazuhiro, Cho, Bryan, Willison, L. David, Palmer, Daniel, Allen, Christopher D.C., Schmidt, Timothy H., Xu, Ying, Proia, Richard L., Coughlin, Shaun R., Cyster, Jason G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158008/
https://ncbi.nlm.nih.gov/pubmed/21642988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2047
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