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Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl
BACKGROUND: The proto-oncogene, c-Abl encodes a ubiquitously expressed tyrosine kinase that critically governs the cell death response induced by genotoxic agents such as ionizing radiation and cisplatin. The catalytic function of Abl, which is essential for executing DNA damage response (DDR), is n...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3157453/ https://ncbi.nlm.nih.gov/pubmed/21781306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-88 |
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