Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl

BACKGROUND: The proto-oncogene, c-Abl encodes a ubiquitously expressed tyrosine kinase that critically governs the cell death response induced by genotoxic agents such as ionizing radiation and cisplatin. The catalytic function of Abl, which is essential for executing DNA damage response (DDR), is n...

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Bibliografske podrobnosti
Main Authors: Jiang, Zhihua, Kamath, Ravindra, Jin, Shunquian, Balasubramani, Manimalha, Pandita, Tej K, Rajasekaran, Baskaran
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157453/
https://ncbi.nlm.nih.gov/pubmed/21781306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-88
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