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Deubiquitination of Tip60 by USP7 Determines the Activity of the p53-Dependent Apoptotic Pathway
Tip60 is an essential acetyltransferase required for acetylation of nucleosomal histones and other nonhistone proteins. Tip60 acetylates the p53 tumor suppressor at lysine 120 (K120), a modification essential for p53-dependent induction of PUMA and apoptosis. It is known that Tip60 is turned over in...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3753911/ https://ncbi.nlm.nih.gov/pubmed/23775119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00358-13 |
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