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Comparison of three GPCR structural templates for modeling of the P2Y(12) nucleotide receptor

The P2Y(12) receptor (P2Y(12)R) is an ADP-activated G protein-coupled receptor (GPCR) that is an important target for antithrombotic drugs. Three homology models of P2Y(12)R were compared, based on different GPCR structural templates: bovine rhodopsin (bRHO), human A(2A) adenosine receptor (A(2A)AR)...

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Autors principals: Deflorian, Francesca, Jacobson, Kenneth A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157290/
https://ncbi.nlm.nih.gov/pubmed/21461952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-011-9423-3
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