Mutations in the BRCT binding site of BRCA1 result in hyper-recombination

We introduced a K1702M mutation in the BRCA1 BRCT domain known to prevent the binding of proteins harboring pS-X-X-F motifs such as Abraxas-RAP80, BRIP1, and CtIP. Surprisingly, rather than impairing homologous recombination repair (HRR), expression of K1702M resulted in hyper-recombination coincidi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Dever, Seth M., Golding, Sarah E., Rosenberg, Elizabeth, Adams, Bret R., Idowu, Michael O., Quillin, John M., Valerie, Nicholas, Xu, Bo, Povirk, Lawrence F., Valerie, Kristoffer
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2011
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156602/
https://ncbi.nlm.nih.gov/pubmed/21666281
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados