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How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH
Delivery of iron to cells requires binding of two iron-containing human transferrin (hTF) molecules to the specific homodimeric transferrin receptor (TFR) on the cell surface. Through receptor-mediated endocytosis involving lower pH, salt, and an unidentified chelator, iron is rapidly released from...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3156180/ https://ncbi.nlm.nih.gov/pubmed/21788477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105786108 |
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