TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells

TNF and epidermal growth factor (EGF) are well-known stimuli of cyclooxygenase (COX)-2 expression, and TNF stimulates transactivation of EGF receptor (EGFR) signaling to promote survival in colon epithelial cells. We hypothesized that COX-2 induction and cell survival signaling downstream of TNF are...

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Autors principals: Hobbs, Stuart S., Goettel, Jeremy A., Liang, Dongchun, Yan, Fang, Edelblum, Karen L., Frey, Mark R., Mullane, Matthew T., Polk, D. Brent
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2011
Matèries:
Hormones and Signaling
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154604/
https://ncbi.nlm.nih.gov/pubmed/21566012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00383.2010
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