TNF-α converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival

Disruption of intestinal epithelial homeostasis, including enhanced apoptosis, is a hallmark of inflammatory bowel disease (IBD). We have recently shown that tumor necrosis factor (TNF) increases the kinase activity of ErbB4, a member of the epidermal growth factor receptor family that is elevated i...

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Hauptverfasser: Hilliard, Valda C., Frey, Mark R., Dempsey, Peter J., Peek, Richard M., Polk, D. Brent
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2011
Schlagworte:
Inflammation/Immunity/Mediators
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154600/
https://ncbi.nlm.nih.gov/pubmed/21617117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00057.2011
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