Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism

Tumor necrosis factor (TNF) and epidermal growth factor (EGF) are key regulators in the intricate balance maintaining intestinal homeostasis. Previous work from our laboratory shows that TNF attenuates ligand-driven EGF receptor (EGFR) phosphorylation in intestinal epithelial cells. To identify the...

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Bibliographic Details
Main Authors: McElroy, Steven J., Frey, Mark R., Yan, Fang, Edelblum, Karen L., Goettel, Jeremy A., John, Sutha, Polk, D. Brent
Format: Artigo
Language:Inglês
Published: American Physiological Society 2008
Subjects:
Inflammation/Immunity/Mediators
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519857/
https://ncbi.nlm.nih.gov/pubmed/18467504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00425.2007
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