TNFR1 Promotes Tumor Necrosis Factor-mediated Mouse Colon Epithelial Cell Survival through RAF Activation of NF-κB

Tumor necrosis factor (TNF) is a therapeutic target in the treatment of inflammatory bowel disease; however, the exact role of TNF signaling in the colon epithelium remains unclear. We demonstrate that TNF activation of TNF receptor (R)1 stimulates both pro- and anti-apoptotic signaling pathways in...

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Detalhes bibliográficos
Main Authors: Edelblum, Karen L., Goettel, Jeremy A., Koyama, Tatsuki, McElroy, Steven J., Yan, Fang, Polk, D. Brent
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Biomolecular Networks
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570867/
https://ncbi.nlm.nih.gov/pubmed/18713739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801269200
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