Restored insulin-sensitivity in IRS-1–deficient mice treated by adenovirus-mediated gene therapy

Insulin resistance is commonly observed both in overt diabetes and in individuals prone to, but not yet manifesting, diabetes. Hence the maintenance or restoration of insulin sensitivity may prevent the onset of this disease. We previously showed that homozygous disruption of insulin receptor substr...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Ueki, Kohjiro, Yamauchi, Toshimasa, Tamemoto, Hiroyuki, Tobe, Kazuyuki, Yamamoto-Honda, Ritsuko, Kaburagi, Yasushi, Akanuma, Yasuo, Yazaki, Yoshio, Aizawa, Sininchi, Nagai, Ryozo, Kadowaki, Takashi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 2000
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC315460/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10811851/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7656
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