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Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease

Insulin signaling has been implicated in the metabolism as well as aging and longevity. Type 2 diabetes mellitus and its core pathology, insulin resistance, has also been implicated in the development of Alzheimer's disease (AD) and amyloid-β deposition in humans. By contrast, genetic ablation of th...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Toshitaka Ochiai, Toshiharu Sano, Takeru Nagayama, Naoto Kubota, Takashi Kadowaki, Tomoko Wakabayashi, Takeshi Iwatsubo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021-11-01
Schriftenreihe:Neurobiology of Disease
Schlagworte:
Alzheimer's disease
Amyloid-beta
Neurodegenerative disease
Tau protein
Insulin
Insulin receptor substrate
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S096999612100259X
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