Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease

Insulin signaling has been implicated in the metabolism as well as aging and longevity. Type 2 diabetes mellitus and its core pathology, insulin resistance, has also been implicated in the development of Alzheimer's disease (AD) and amyloid-β deposition in humans. By contrast, genetic ablation of th...

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Hlavní autoři:	Toshitaka Ochiai, Toshiharu Sano, Takeru Nagayama, Naoto Kubota, Takashi Kadowaki, Tomoko Wakabayashi, Takeshi Iwatsubo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2021-11-01
Edice:	Neurobiology of Disease
Témata:	Alzheimer's disease Amyloid-beta Neurodegenerative disease Tau protein Insulin Insulin receptor substrate
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S096999612100259X
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