CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV

We raised monoclonal antibodies against senile plaque (SP) amyloid and obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with ∼50/100 kDa polypeptides in Alzheimer’s disease (AD) brains. We purified the 9D2 antigens and cloned a cDNA encoding its precursor, which was a novel typ...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Hashimoto, Tadafumi, Wakabayashi, Tomoko, Watanabe, Atsushi, Kowa, Hisatomo, Hosoda, Ritsuko, Nakamura, Atsushi, Kanazawa, Ichiro, Arai, Takao, Takio, Koji, Mann, David M.A., Iwatsubo, Takeshi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125364/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11927537/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.7.1524
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