CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV

We raised monoclonal antibodies against senile plaque (SP) amyloid and obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with ∼50/100 kDa polypeptides in Alzheimer’s disease (AD) brains. We purified the 9D2 antigens and cloned a cDNA encoding its precursor, which was a novel typ...

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Autores principales: Hashimoto, Tadafumi, Wakabayashi, Tomoko, Watanabe, Atsushi, Kowa, Hisatomo, Hosoda, Ritsuko, Nakamura, Atsushi, Kanazawa, Ichiro, Arai, Takao, Takio, Koji, Mann, David M.A., Iwatsubo, Takeshi
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC125364/
https://ncbi.nlm.nih.gov/pubmed/11927537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.7.1524
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