Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease

Insulin signaling has been implicated in the metabolism as well as aging and longevity. Type 2 diabetes mellitus and its core pathology, insulin resistance, has also been implicated in the development of Alzheimer's disease (AD) and amyloid-β deposition in humans. By contrast, genetic ablation of th...

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Principais autores:	Toshitaka Ochiai, Toshiharu Sano, Takeru Nagayama, Naoto Kubota, Takashi Kadowaki, Tomoko Wakabayashi, Takeshi Iwatsubo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-11-01
Colecção:	Neurobiology of Disease
Assuntos:	Alzheimer's disease Amyloid-beta Neurodegenerative disease Tau protein Insulin Insulin receptor substrate
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S096999612100259X
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