Aspartyl-(asparaginyl) β-Hydroxylase, Hypoxia-Inducible Factor-1α and Notch Cross-Talk in Regulating Neuronal Motility

Aspartyl-(Asparaginyl)-β-Hydroxylase (AAH ) promotes cell motility by hydroxylating Notch. Insulin and insulin-like growth factor, type 1 (IGF-I) stimulate AAH through Erk MAP K and phosphoinositol-3-kinase-Akt (PI3K-Akt). However, hypoxia/oxidative stress may also regulate AAH . Hypoxia-inducible f...

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Detalhes bibliográficos
Main Authors: Lawton, Margot, Tong, Ming, Gundogan, Fusun, Wands, Jack R., de la Monte, Suzanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154035/
https://ncbi.nlm.nih.gov/pubmed/21150341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/oxim.3.5.13296
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