Role of aspartyl-(asparaginyl)-β-hydroxylase mediated notch signaling in cerebellar development and function

BACKGROUND: Aspartyl-(Asparaginyl)-β-Hydroxylase (AAH) is a hydroxylating enzyme that promotes cell motility by enhancing Notch-Jagged-HES-1 signaling. Ethanol impaired cerebellar neuron migration during development is associated with reduced expression of AAH. METHODS: To further characterize the r...

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Bibliografiske detaljer
Main Authors: Silbermann, Elizabeth, Moskal, Peter, Bowling, Nathaniel, Tong, Ming, de la Monte, Suzanne M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988696/
https://ncbi.nlm.nih.gov/pubmed/21050474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-9081-6-68
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