Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes

The mammalian heart loses its regenerative potential soon after birth. Adult cardiac myocytes (ACMs) permanently exit the cell cycle, and E2F-dependent genes are stably silenced, although the underlying mechanism is unclear. Heterochromatin, which silences genes in many biological contexts, accumula...

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Bibliographische Detailangaben
Hauptverfasser: Sdek, Patima, Zhao, Peng, Wang, Yaping, Huang, Chang-jiang, Ko, Christopher Y., Butler, Peter C., Weiss, James N., MacLellan, W. Robb
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2011
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153646/
https://ncbi.nlm.nih.gov/pubmed/21825075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201012049
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