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Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes
The mammalian heart loses its regenerative potential soon after birth. Adult cardiac myocytes (ACMs) permanently exit the cell cycle, and E2F-dependent genes are stably silenced, although the underlying mechanism is unclear. Heterochromatin, which silences genes in many biological contexts, accumula...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3153646/ https://ncbi.nlm.nih.gov/pubmed/21825075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201012049 |
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