Kinetic Analysis of Substrate Utilization by Native and TNAP-, NPP1-, or PHOSPHO1-Deficient Matrix Vesicles

During the process of endochondral bone formation, chondrocytes and osteoblasts mineralize their extracellular matrix by promoting the formation of hydroxyapatite seed crystals in the sheltered interior of membrane-limited matrix vesicles (MVs). Here, we have studied phosphosubstrate catalysis by os...

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Main Authors: Ciancaglini, Pietro, Yadav, Manisha C, Simão, Ana Maria Sper, Narisawa, Sonoko, Pizauro, João Martins, Farquharson, Colin, Hoylaerts, Marc F, Millán, José Luis
Format: Artigo
Jezik:Inglês
Izdano: Wiley Subscription Services, Inc., A Wiley Company 2010
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153326/
https://ncbi.nlm.nih.gov/pubmed/19874193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/jbmr.091023
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