Kinetic Analysis of Substrate Utilization by Native and TNAP-, NPP1-, or PHOSPHO1-Deficient Matrix Vesicles

During the process of endochondral bone formation, chondrocytes and osteoblasts mineralize their extracellular matrix by promoting the formation of hydroxyapatite seed crystals in the sheltered interior of membrane-limited matrix vesicles (MVs). Here, we have studied phosphosubstrate catalysis by os...

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Bibliographic Details
Main Authors: Ciancaglini, Pietro, Yadav, Manisha C, Simão, Ana Maria Sper, Narisawa, Sonoko, Pizauro, João Martins, Farquharson, Colin, Hoylaerts, Marc F, Millán, José Luis
Format: Artigo
Language:Inglês
Published: Wiley Subscription Services, Inc., A Wiley Company 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153326/
https://ncbi.nlm.nih.gov/pubmed/19874193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/jbmr.091023
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