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Regulatory Revolution- Evolving the “Anti-LacI” Repressor
Much of adaptation is based upon changes in gene expression, but the emergence of new regulatory logic has not been observed directly. Now Poelwijk et al. report evolving the lac repressor (LacI) to reverse its regulatory logic, resulting in an “anti-LacI” that represses transcription when bound to...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3152793/ https://ncbi.nlm.nih.gov/pubmed/21816271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.07.015 |
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