Toll-like receptor 7 (TLR7)–driven accumulation of a novel CD11c(+) B-cell population is important for the development of autoimmunity

Females are more susceptible than males to many autoimmune diseases. The processes causing this phenomenon are incompletely understood. Here, we demonstrate that aged female mice acquire a previously uncharacterized population of B cells that we call age-associated B cells (ABCs) and that these cell...

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Detalhes bibliográficos
Main Authors: Rubtsov, Anatoly V., Rubtsova, Kira, Fischer, Aryeh, Meehan, Richard T., Gillis, Joann Z., Kappler, John W., Marrack, Philippa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152497/
https://ncbi.nlm.nih.gov/pubmed/21543762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-331462
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