Flip-flop pharmacokinetics – delivering a reversal of disposition: challenges and opportunities during drug development

Flip-flop pharmacokinetics is a phenomenon often encountered with extravascularly administered drugs. Occurrence of flip-flop spans preclinical to human studies. The purpose of this article is to analyze both the pharmacokinetic interpretation errors and opportunities underlying the presence of flip...

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Bibliografiske detaljer
Main Authors: Yáñez, Jaime A, Remsberg, Connie M, Sayre, Casey L, Forrest, M Laird, Davies, Neal M
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152312/
https://ncbi.nlm.nih.gov/pubmed/21837267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/tde.11.19
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