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Flip-flop pharmacokinetics – delivering a reversal of disposition: challenges and opportunities during drug development
Flip-flop pharmacokinetics is a phenomenon often encountered with extravascularly administered drugs. Occurrence of flip-flop spans preclinical to human studies. The purpose of this article is to analyze both the pharmacokinetic interpretation errors and opportunities underlying the presence of flip...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3152312/ https://ncbi.nlm.nih.gov/pubmed/21837267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/tde.11.19 |
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