Intracellular Serine Protease Inhibitor SERPINB4 Inhibits Granzyme M-Induced Cell Death

Granzyme-mediated cell death is the major pathway for cytotoxic lymphocytes to kill virus-infected and tumor cells. In humans, five different granzymes (i.e. GrA, GrB, GrH, GrK, and GrM) are known that all induce cell death. Expression of intracellular serine protease inhibitors (serpins) is one of...

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Detalhes bibliográficos
Main Authors: de Koning, Pieter J. A., Kummer, J. Alain, de Poot, Stefanie A. H., Quadir, Razi, Broekhuizen, Roel, McGettrick, Anne F., Higgins, Wayne J., Devreese, Bart, Worrall, D. Margaret, Bovenschen, Niels
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152296/
https://ncbi.nlm.nih.gov/pubmed/21857942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022645
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