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The transcription factors STAT5A and STAT5B negatively regulate cell proliferation through the activation of Cdkn2b and Cdkn1a expression

Although the cytokine-inducible transcription factors STAT5 promote proliferation of a wide range of cell types, there are cell- and context specific cases in which loss of STAT5 results in enhanced cell proliferation. Here we report that loss of STAT5 from mouse embryonic fibroblasts (MEFs) leads t...

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Detalhes bibliográficos
Main Authors: Yu, Ji Hoon, Zhu, Bing-Mei, Wickre, Mark, Riedlinger, Gregory, Chen, Weiping, Hosui, Atsushi, Robinson, Gertraud W., Hennighausen, Lothar
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152209/
https://ncbi.nlm.nih.gov/pubmed/21038417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23882
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