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Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation
The molecular mechanisms underlying the development of hepatocellular carcinoma are not fully understood. Liver-specific signal transducer and activator of transcription (STAT) 5A/B–null mice (STAT5-LKO) were treated with carbon tetrachloride (CCl(4)), and histological analyses revealed liver fibros...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715112/ https://ncbi.nlm.nih.gov/pubmed/19332876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080003 |
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