Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation

The molecular mechanisms underlying the development of hepatocellular carcinoma are not fully understood. Liver-specific signal transducer and activator of transcription (STAT) 5A/B–null mice (STAT5-LKO) were treated with carbon tetrachloride (CCl(4)), and histological analyses revealed liver fibros...

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Bibliographic Details
Main Authors: Hosui, Atsushi, Kimura, Akiko, Yamaji, Daisuke, Zhu, Bing-mei, Na, Risu, Hennighausen, Lothar
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715112/
https://ncbi.nlm.nih.gov/pubmed/19332876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080003
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