Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity

The molecular mechanism of factor Xa (FXa) inhibition by Alboserpin, the major salivary gland anticoagulant from the mosquito and yellow fever vector Aedes albopictus, has been characterized. cDNA of Alboserpin predicts a 45-kDa protein that belongs to the serpin family of protease inhibitors. Recom...

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Detalhes bibliográficos
Main Authors: Calvo, Eric, Mizurini, Daniella M., Sá-Nunes, Anderson, Ribeiro, José M. C., Andersen, John F., Mans, Ben J., Monteiro, Robson Q., Kotsyfakis, Michail, Francischetti, Ivo M. B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151045/
https://ncbi.nlm.nih.gov/pubmed/21673107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.247924
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