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Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity

The molecular mechanism of factor Xa (FXa) inhibition by Alboserpin, the major salivary gland anticoagulant from the mosquito and yellow fever vector Aedes albopictus, has been characterized. cDNA of Alboserpin predicts a 45-kDa protein that belongs to the serpin family of protease inhibitors. Recom...

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Main Authors: Calvo, Eric, Mizurini, Daniella M., Sá-Nunes, Anderson, Ribeiro, José M. C., Andersen, John F., Mans, Ben J., Monteiro, Robson Q., Kotsyfakis, Michail, Francischetti, Ivo M. B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151045/
https://ncbi.nlm.nih.gov/pubmed/21673107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.247924
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