Structural basis for complement factor I control and its disease-associated sequence polymorphisms

The complement system is a key component of innate and adaptive immune responses. Complement regulation is critical for prevention and control of disease. We have determined the crystal structure of the complement regulatory enzyme human factor I (fI). FI is in a proteolytically inactive form, demon...

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Detaylı Bibliyografya
Asıl Yazarlar: Roversi, Pietro, Johnson, Steven, Caesar, Joseph J. E., McLean, Florence, Leath, Kirstin J., Tsiftsoglou, Stefanos A., Morgan, B. Paul, Harris, Claire L., Sim, Robert B., Lea, Susan M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150940/
https://ncbi.nlm.nih.gov/pubmed/21768352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102167108
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