Structural basis for complement factor I control and its disease-associated sequence polymorphisms

The complement system is a key component of innate and adaptive immune responses. Complement regulation is critical for prevention and control of disease. We have determined the crystal structure of the complement regulatory enzyme human factor I (fI). FI is in a proteolytically inactive form, demon...

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Autores principales: Roversi, Pietro, Johnson, Steven, Caesar, Joseph J. E., McLean, Florence, Leath, Kirstin J., Tsiftsoglou, Stefanos A., Morgan, B. Paul, Harris, Claire L., Sim, Robert B., Lea, Susan M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150940/
https://ncbi.nlm.nih.gov/pubmed/21768352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102167108
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