Structural basis for complement factor H–linked age-related macular degeneration

Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His substitution at position 402, is linked to ∼50% of att...

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Detalhes bibliográficos
Main Authors: Prosser, Beverly E., Johnson, Steven, Roversi, Pietro, Herbert, Andrew P., Blaum, Bärbel S., Tyrrell, Jess, Jowitt, Thomas A., Clark, Simon J., Tarelli, Edward, Uhrín, Dušan, Barlow, Paul N., Sim, Robert B., Day, Anthony J., Lea, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118454/
https://ncbi.nlm.nih.gov/pubmed/17893204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071069
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