Dimerization of complement factor H-related proteins modulates complement activation in vivo

The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within the complement factor H-related (CFHR) locus. Elucidating the mechanism underlying these associations ha...

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Autors principals: Goicoechea de Jorge, Elena, Caesar, Joseph J. E., Malik, Talat H., Patel, Mitali, Colledge, Matthew, Johnson, Steven, Hakobyan, Svetlana, Morgan, B. Paul, Harris, Claire L., Pickering, Matthew C., Lea, Susan M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606973/
https://ncbi.nlm.nih.gov/pubmed/23487775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219260110
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