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Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation

SNARE proteins play a critical role in intracellular membrane fusion by forming tight complexes that bring two membranes together and involve sequences called SNARE motifs. These motifs have a high tendency to form amphipathic coiled-coils that assemble into four-helix bundles, and often precede tra...

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Autori principali: Brewer, Kyle D., Li, Wei, Horne, Bethany Erin, Rizo, Josep
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150886/
https://ncbi.nlm.nih.gov/pubmed/21768342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105128108
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