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Structure and stability of the lamin A tail domain and HGPS mutant

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging syndrome caused by the expression and accumulation of a mutant form of lamin A, Δ50 lamin A. As a component of the cell's nucleoskeleton, lamin A plays an important role in the mechanical stabilization of the nuclear envelope and...

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Bibliografiske detaljer
Main Authors: Qin, Zhao, Kalinowski, Agnieszka, Dahl, Kris Noel, Buehler, Markus J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150306/
https://ncbi.nlm.nih.gov/pubmed/21635954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2011.05.015
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