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MHC Class I and TCR Avidity Control the CD8 T Cell Response to IL-15/IL-15Rα Complex
IL-15 operates via a unique mechanism termed transpresentation. In this system, IL-15 produced by one cell type is bound to IL-15Rα expressed by the same cell and is presented to apposing cells expressing the IL-15Rβ/γC complex. We have shown that administering soluble IL-15Rα complexed with IL-15 c...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3150213/ https://ncbi.nlm.nih.gov/pubmed/21041729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001601 |
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