A Gene Optimization Strategy that Enhances Production of Fully Functional P-Glycoprotein in Pichia pastoris

BACKGROUND: Structural and biochemical studies of mammalian membrane proteins remain hampered by inefficient production of pure protein. We explored codon optimization based on highly expressed Pichia pastoris genes to enhance co-translational folding and production of P-glycoprotein (Pgp), an ATP-d...

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Autors principals: Bai, Jiangping, Swartz, Douglas J., Protasevich, Irina I., Brouillette, Christie G., Harrell, Patina M., Hildebrandt, Ellen, Gasser, Brigitte, Mattanovich, Diethard, Ward, Andrew, Chang, Geoffrey, Urbatsch, Ina L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149604/
https://ncbi.nlm.nih.gov/pubmed/21826197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022577
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